Kinase inhibitors and methods of their use
New compounds, compositions and methods of inhibition of Provirus Integration of Maloney Kinase (PIM kinase) activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and comp...
Burger, Matthew，Lindvall, Mika，W Han，... - US
Insulin-like growth factor receptor inhibitors
The success of targeted therapies for cancer is undisputed; strong preclinical evidence has resulted in the approval of several new agents for cancer treatment. The type I insulin-like growth factor receptor (IGF1R) appeared to be one of...
D Yee - 《Journal of the National Cancer Institute》
Zusammensetzung zur hemmung von cathepsin k
The present invention relates to the a method of inhibiting bone resorption in a mammal in need thereof with an oral pharmaceutical composition comprising a cathepsin K inhibitor, or a pharmaceutically acceptable salt thereof, or a mixtu...
A Daifotis，SA Stoch，BA Ince，... - EP
Substituted benzimidazoles and methods of their use
Substituted benzimidazoles and methods of their use., , , , , , , , , , , The Patent Description & Claims data below is from USPTO Patent Application 20090...
N Ag
PIM KINASE INHIBITORS AND METHODS OF THEIR USE
New compounds, compositions and methods of inhibition of kinase activity associated with tumorigenesis in a human or animal subject are provided. In certain embodiments, the compounds and compositions are effective to inhibit the activit...
BURGER Matthew，LINDVALL Mika，HAN Wooseok，... - WO
AMIDE SUBSTITUTED INDAZOLES AS POLY(ADP-RIBOSE)POLYMERASE (PARP) INHIBITORS
The present invention relates to combinations of compounds of formula I: and other anti-cancer agents which are useful for the treatment of cancer, inflammatory diseases, reperfusion injuries, ischemic conditions, stroke, renal failure,...
Jones; Philip，Ontoria Ontoria; Jesus Maria，Scarpelli; Rita，... - EP
INDAZOLE DERIVATIVES USEFUL AS ERK INHIBITORS
The present invention provides a compound of the Formula I, or a pharmaceutically acceptable salt, solvate or ester thereof, wherein R, R1, R2, R3, m and are as defined herein. The... 查看全部>>
SIE-MUN - WO
THIOPHENE AND THIAZOLE SUBSTITUTED TRIFLUOROETHANONE DERIVATIVES AS HISTONE DEACETYLASE (HDAC) INHIBITORS
PROBLEM TO BE SOLVED: To provide thiophene and thiazole substituted trifluoroethanone derivatives that are inhibitors of histone deacetylase (HDAC), particularly class II HDAC.
F Ferrigno，フェリーニョ,フェデリカ，J Philip，...
Selective androgen receptor modulator (SARM) and uses thereof
Provided herein are compounds of formulae I to II that bind to androgen receptors and/or modulate activity of androgen receptors; and to methods for making...
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Intermediates and processes for 6-carboxy HMG-CoA reductase inhibitors
This invention discloses intermediates and a process for the preparation of 6-desmethyl-6-carboxy derivatives of lovastatin and analogs thereof at the 9-acyl side chain.
TJ Lee，WF Hoffman - CA
