ML-236B Derivatives

Compounds of formula (I): ##STR1## (wherein R represents a group of formula ##STR2## and the corresponding ring-closed lactones, salts (especially alkali metal salts) and esters (especially C.sub.1 -C. sub.5 alkyl esters) thereof may be ...

A Terahara，M Tanaka - US

One-step

Mevinolin, compactin and dihydro- and tetrahydro derivatives thereof are converted to more active HMG-CoA reductase inhibitors by C-methylation of the natu...

M Sleteinger，TR Verhoeven，RP Volante - US

HMG-COA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the f...

KP Vyas，HP Kari - US

Octahydronaphthalene derivatives and their preparation

Compounds of formula (I): ##STR1## [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and Rand Rare the same or different and each represents an oxygen atom or a group of form...

J Ide，S Muramatsu，Y Tsujita，... - US

Octahydronaphthalene derivatives and their preparation

Compounds of formula (I): [wherein X represents a hydrogen atom or a 2-methylbutyryl group, Y represents a hydrogen atom or a methyl group and R and R are the same or different and each represents an oxygen atom or a group of formula =- ...

IJC Laboraties，MSC Laboraties，TYF Laboratories，... - US

Process for C-methylation of 2-methylbutyrates

Mevinolin, compactin and dihydro- and tetrahydro derivatives thereof are converted to more active HMG-CoA reductase inhibitors by C-methylation of the natu...

M Sleteinger，Verhoeven, Thomas R.，Volante, Ralph P. - US

Antihypercholesterolemic agents

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents are represented by the following structural formulae (I) and (II): ##STR1## are disclosed.

RA Reamer，LR Treiber - US

6(R)-(2-(8'-ETHERIFIED-HYDROXY-2',6'-DIMETHYLPOLYHYDRO-NAPHTHYL-1')-ETHYL)-4(R)-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES, THE HYDROXY ACID FORM OF SAID PYRANONES, THE SALTS OF SAID ACID FORM, PROCESS FOR PREPARING THE SAME AND AN ANTIH...

6(R)-[2-(8'-Etherified-hydroxy-2',6'- dimethyl- polyhydronaphthyl-1') -ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones are prepared from the corresponding 8'-acyloxy compounds, some of which are naturally occurring, by protection ...

SMITH, ROBERT L.，LEE, TA-JYH - EP

Octahydronaphthalene derivatives and their preparation

NEW MATERIAL:A compound of formulaIor II[X is H or 2-methylbutyryl; Y is H or CH3; R<1> and R<2> are O or =N-OR<4> (R<4> is H or lower alkyl); R<3> is H or lower alkyl]and a salt thereof. EXAMPLE:3,4-Dihydroxy-6-oxo-4-hydroxyiminoiso ML-...

Ide Junya Chemical Research Laboraties，Muramatsu Shigeki Chemical Research Laboraties，Tsujita Yoshio Fermentation Research Laboratories，...

HMG-CoA reductase inhibitors

Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors which are useful as antihypercholesterolemic agents and are represented by the f...

BH Arison，MD Greenspan，JB Yudkovitz - US