Synthesis, spectroscopic characterization and biocidal activity of some diorganotin(IV) complexes of salicylaldehydethiosemicarbazones and related ligands. Molecular and supramolecular structures of [R2Sn(OArCHNNCSNH2)], where R = Me, Ph and Ar =

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作者：

MS Sarma，S Mazumder，D Ghosh，A Roy，A Duthie，ERT Tiekink

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摘要：

Nine diorganotin(IV) compounds of Schiff bases derived from salicylaldehyde/substituted salicylaldehyde and thiosemicarbazide were synthesized. The compounds, with general formulae [R 2 Sn(OArCH N N CSNH 2 )], where R = Me, n -Bu, Ph and Ar = C 6 H 4 , C 6 H 3 (5-Cl), C 6 H 3 (5-Br), were characterized by UV and IR spectroscopy, NMR ( 1 H, 13 C and 119 Sn) spectroscopy and elemental analysis. X-ray crystallographic studies of five of these complexes indicate penta-coordination of tin within a distorted C 2 NOS trigonal bipyramidal geometry in each case. The crystal packing in four of the structures features {··· N C N H} 2 synthons, but in [Ph 2 Sn(OArCH N N CSNH 2 )] the {··· S C N H} 2 synthon is predominant. The biological activity of these compounds against four fungal pathogens ( Curvularia eragrostidis, Alternaria porri, Dreschlerea oryzae and Macrophomina phaseolina ) of four different crops ( Camellia sineusis, Guizotia abyssinica, Oryzae sativa and Solanum melongena) and some bacteria ( Aeromonas hydrophila, Salmonella typhi, Salmonella typhimurium, Salmonella flexnri, Escheria coli, Salmonella aureus, Bacillus subtilis and Lactobacillus rhamnosus ) were investigated. Their cytotoxicity was also investigated against several human cancer cell lines. Copyright 2007 John Wiley & Sons, Ltd.

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关键词：

tin(IV organotin crystal structure biocidal activity cytotoxicity thiosemicarbazones

DOI：

10.1002/aoc.1301

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年份：

2007