STAT5 regulates the self-renewal capacity and differentiation of human memory B cells and controls Bcl-6 expression
摘要：
It is unknown how B cells that mature during a germinal center reaction 'decide' between plasma or memory cell fate. Here we describe a previously unknown subpopulation of B cells in the human germinal center that is characterized by tyrosine phosphorylated transcriptional activator STAT5. These cells had an activated centrocyte phenotype and had abundant expression ofbut low expression of, both encoding transcriptional repression proteins. Using RNA interference and ectopic expression of constitutively activated forms of STAT5, we demonstrate here a function for STAT5 in the self-renewal of B cells. STAT5b isoform seemed to directly upregulate Bcl-6, and ectopic expression of Bcl-6 in B cells resulted in self-renewal and inhibition of plasma cell differentiation. These data indicate that activation of STAT5 is involved in regulation of memory B cell differentiation.
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关键词：
GERMINAL-CENTER FORMATION GENE-EXPRESSION PLASMA-CELLS T-CELL C-MYC TERMINAL DIFFERENTIATION SIGNAL TRANSDUCER IN-VITRO TRANSCRIPTION LYMPHOCYTE
DOI：
10.1039/b404874c
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