Studies on chemical constituents from Euonymus alatus Ⅱ
摘要：
Objective:To study the chemical constituents and antitumor activities of Euonymus alatus.Method:Compounds were isolated and purified repeatedly by silica gel,Sephadex LH-20 column chromatography,and their chemical structures were elu- cidated by their physiconhemical properties and spectral data,such as ~1H-NMB,~(13)C-NMR and EI-MS.The trypan blue experiments in vitro were used to observe the antitumor activity of several compounds.Result:Ten compounds were obtained and identified as(+)- usnic acid(1),benzoic acid(2),2-hydroxy-4-methoxy-3,6-dimethyl benzoic acid(3),lupeol(4),3β-hydroxy-30-norlupan-20- one(5),(2R,3R)-3,5,7,4'-tetrahydroxy flavanone(6),kaempferol(7),5,7,4'-trihydroxy flavanone(8),quercetin(9)and daucosterol(10).Condusion:Compounds 1,2,5 and 8 were isolated from this genus for the first time.The trypan blue experiments in vitro showed that compounds 1,4 and 5 had growth inhibitory effects on HL-60 cells.
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年份：
2008
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