Compositions comprising microparticles of water-insoluble substances and method for preparing same
申请(专利)号：
KR19997001435
申请日期：
1999-02-22
公开/公告号：
KR20000035808A
公开/公告日期：
2000-06-26
申请(专利权)人：
RESEARCH TRIANGLE PHARMACEUTICALS
被引量：
摘要：
通过使用一种或多种表面改性剂/表面活性剂,如Polaxomers,Poloxamines,聚氧乙烯脱水甘露糖醇脂肪酸酯等与天然的或合成的磷脂一起组合来制备药物或其他水不溶或难溶于水的物质的亚微米大小的颗粒. By using one or more surface modifying agents / surfactants, such as the combination with natural or synthetic phospholipids Polaxomers, Poloxamines, polyoxyethylenesorbitan fatty acid esters of mannitol to the preparation of pharmaceutical or other water-insoluble or poorly submicron sized water-insoluble particulate matter. 这样生成的颗粒具有的体积重量的平均颗粒大小至少要比单独应用磷脂所得到的小一半. The average particle size of the thus-produced particles have a volume weight of at least than the phospholipids alone obtained small half. 这样得到的组合物在贮存时可以阻止颗粒大小的增长. The composition thus obtained can be prevented during storage increase particle size.
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