Composition and method of preparing microparticles of water- insoluble substances

Submicron size particles of pharmaceutical or other water- insoluble or poorly water-insoluble substances are prepared using a combination of one or more surface modifiers/surfactants such as polaxomers, poloxamines, polyoxyethylene sorb...

I Parikh，U Selvaraj - US

Method for preparing submicron particle suspensions

The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process...

JE Kipp，JCT Wong，MJ Doty，... - EP

Controlled release nanoparticulate compositions

Described are controlled release nanoparticulate formulations comprising a nanoparticulate agent to be administered and a rate-controlling polymer which functions to prolong the release of the agent following administration. The novel co...

S Jon，RA Jain，H Robert，...

In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate or nanoparticulate active agent compositions

Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media representative of in vivo human physiological conditions.

ER Cooper，JA Bullock，JR Chippari，... - US

Formulation for topical non-invasive application in vivo

A formulation comprising molecular arrangements capable of penetrating pores in a barrier, owing to penetrant adaptability, despite the fact that the average diameter of said pores is smaller than the average penetrant diameter, provided...

G Cevc - WO

Redispersing a dosage form, comprising a poorly water-soluble active agent, measuring particle size and determining if the level of redispersibility is suf...

Disclosed are in vitro methods for evaluating the in vivo redispersibility of dosage forms of poorly water-soluble active agents. The methods utilize media...

ER Cooper，JA Bullock，JR Chippari，... - US

Preparation of submicron sized nanoparticles via dispersion lyophilization

The present invention relates to a process for preparing submicron sized nanoparticles of a poorly water soluble compound by lyophilizing a dispersion or m...

S Brynjelsen，M Doty，JE Kipp，...

PROCESSES TO GENERATE SUBMICRON PARTICLES OF WATER-INSOLUBLE COMPOUNDS

Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compre...

PACE Gary W.，VACHON G. Michael，MISHRA K. Awadhesh，... - US

Nanoparticulate compositions of mitogen-activated protein (MAP) kinase inhibitors

Nanoparticulate compositions comprising at least one poorly soluble MAP kinase inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The in...

HW Bosch，GG Cary，DC Hovey，... - US

Pro-nanodispersion for the delivery of cyclosporin

A novel cyclosporine formulation, which is a pro-nanodispersion at room temperature, featuring solid particles of a relatively large particle size (at least about 150 nm) and yet which is a microdispersion at body temperature.

DOMB, Abraham J.，AVRAMOFF, Avi，PEVZNER, Victor - WO